This lecture provides an overview of the endocrine system, focusing on hormone secretion, regulation through negative feedback, and key glands such as the hypothalamus, pituitary, thyroid, adrenal glands, and pancreas. It explains the mechanisms of hormone stimuli including humoral, neural, and hormonal triggers, and details the interactions between the hypothalamus and pituitary gland in regulating hormone release. The thyroid gland is used as a model to illustrate negative feedback systems essential for maintaining hormonal balance.